Introduction
Puzzle Quest is pretty fun.
If you haven't tried it yet, it's almost definitely available on any platform choice - it's on the Sony PSP, Nintento DS, PC (Intel GMA 950 is probably enough), Playstation Network (for PS3), XBLA (for XBOX 360), iPhone/iPod touch, and most other mobile platforms (although our affiliate Clickgamer unfortunately doesn't seem to carry it).
Anyhow, I've been playing it, on the PC (on which it looks pretty and has a easy mouse interface) although I've tested the iPhone and PSP versions (iPhone is slow, fiddly, PSP interface is not ideal). The PC version also appears to have mods - LINK - note that I have not tried them all.
History
The game was first released on the DS/PSP in early 2007, and those versions were pretty sweet - you could build characters which could annhilate an opponent in a single round (not luck based). However, at least the PC version has been... reduced, such that the best spells are now quite limited. Having said that, you can still build pretty potent characters, but the methodology isn't obvious from GameFAQs (although it's useful), and the combinations suggested from some type of mathamatical analysis are (generally) wrong.
So, how to build a dreamy character?
Classes
While I say "new", I know that the iPhone and some other versions have classes which I will not be dealing with, but in general the same principles (see end of article) should apply. For the PC version, the Knight is in the most difficult situation (although I haven't played one to 50 yet, might decide to, but I just can't see how to overcome luck consistently in the new PC version).
Assuming you don't update to 1.02, the Druid is the best, if you research Death Gaze. (Version 1.02 reduces the strength of the holy lance/unholy lance).
Wizard is second, Warrior is close behind (although both of these don't require you to research anything).
Equipment
First off, equipment. You can wear four types of items, head, weapon, body and misc. In general the best weapons need to be forged - the one who waits.com has a great section showing what can be made. To figure out where to find specific runes, use the map hosted by Infinite Interactive.
The best items are as follows:
Head: Rune of Jewels (head item) + Rune of Gods + Rune of (pick mana colour).
Body: Rune of (pick any body rune) + Rune of Gods + Rune of (pick mana colour).
Weapon: Firewalker's Staff (warrior/wizard), Holy Lance (Druid).
Misc: Rune of Music + Rune of Dragons + Rune of (pick mana colour).
Changes in the "New"
For the old versions, the key was to have enough mana (from your equipment), right from the beginning, to cast your "best" spell. For Warriors, Deathbringer. Wizards, Flaming Skulls. Knights and Druids, Death Gaze. The only spell which has not changed in the PC version is Flaming Skulls.
If you also have the appropriate skill pumped up (Warriors/Wizards, Fire - Druids, Air - Knight, probably battle), then you'd probably win right away.
Unfortunately (or, fortunately) Deathbringer and Death Gaze are now restricted to creating a maximum of 10 skulls, which means that you had better make sure you are using them only when there is a decent number of skulls (say, 10) or if you have no choice, no skulls, on the board. Otherwise, you're likely setting the opponent up (to pwn you).
To make matters worse, the forged equipment is also worse. Instead of +8 mana, a rune now gives +2 mana.
The weapons have also been toned down. Firewalker's Staff only adds half the damage it used to.
Finally, for spells with recharge, it appears that they recharge only when the opponent takes a turn, not when you get a "free turn".
Strategy
What do you do? Well, if you're a Druid, you can forge equipment so that you can cast Evaporate immediately, or as soon as you get a blue/yellow 4-in-a-row. Then cast Gust of Wind (you should have at least 40/50 yelllow). Reincarnation is also useful. In any event, because you can fill your mana reserves, you can then cast Death Gaze quite easily, and since Death Gaze doesn't use yellow, random skull matches afterwards will still do lots of damage.
For Wizards, just watch for the 4-in-a-row green/skulls or blue/red and use flaming skulls as appropriate.
For Warriors, look for 4-in-a-row red/skulls, or simply do Beserk Rage to get skulls on the table then hope that a Deathbringer sets them off.
Skill distribution
Druid:
39 earth (for 45 green mana, note that you can get +2 from a quest)
10 fire (for 30 red mana, note that you get +4 from a quest)
every thing else to Yellow (for Holy Lance).
Warrior/Wizard: everything to Red (for Firewalker's Staff)
So, principles: 1. Find spell/equipment. 2. Distribute experience to maximise the spell/weapon. 3. always have a dragonhorn (rune of music + rune of dragon forged item)